In April 2019, Keke Palmer began guest co-hosting ABC’s daytime talk show Strahan and Sara, sporadically filling in for co-host Michael Strahan and more regularly beginning in June during co-host Sara Haines’ maternity leave. She joined the slasher television series Scream as a series regular in its third season, portraying a character named Kym Johnson, which premiered on July 8, 2019. On August 26, Palmer became a third permanent co-host of Strahan and Sara, which was then re-titled Strahan, Sara and Keke. In September, Palmer starred as a “lovestruck stripper” in the crime drama film Hustlers, directed by Lorene Scafaria. She sang the song “Giants” as part of a virtual group named True Damage, in which she voices a character named Senna, in the video game League of Legends for the 2019 World Championship. The song features singers Becky G and Soyeon as well as rappers Duckwrth and Thutmose as the other group members. In November, True Damage performed the song live during the opening ceremony of the finals. Strahan, Sara and Keke was taken off the air in March 2020. Palmer later received a Daytime Emmy Award nomination for Outstanding Entertainment Talk Show Host alongside Haines and Strahan. That same year, Palmer began starring in a web television comedy series titled Turnt Up with the Taylors, in which she portrays all of the characters. She released an extended play titled Virgo Tendencies, Pt. 1 on August 28. On August 30, Palmer hosted the 2020 MTV Video Music Awards, during which she also performed her song “Snack”. She released a follow-up EP – Virgo Tendencies, Pt. 2 – in December 2020. The following year, Palmer won the Primetime Emmy Award for Outstanding Actress in a Short Form Comedy or Drama Series for her performance in Turnt Up with the Taylors.
Keke Palmer played at Nope -an horror film written and directed by Jordan Peele. The movie is scheduled to be released by Universal Pictures on July 22, 2022.