Dominique Fishback first major recurring role was in the Yonkers housing drama Show Me a Hero as single mother Billie Rowan. Her first series regular role is in the 1970s Times Square drama The Deuce. Fishback has been noted as one of the standouts in the show due to her performance as the “sweetly vulnerable” prostitute Darlene. Co-creator David Simon has noted her strengths as an actress in playing Darlene. For her role on The Deuce, Fishback was listed by USA Today as one of five new faces that people should be watching on fall 2017 television. Her first film is Night Comes On, which premiered at the 2018 Sundance Film Festival. She played the part of Kenya in the film The Hate U Give (2018), which is based on the popular young adult book. Also in 2018, Fishback appeared as a younger version of Jay-Z’s mother, Gloria Carter, in his music video for “Smile.” Fishback plays a street-smart teenager in Project Power, directed by Ariel Schulman and Henry Joost, opposite Jamie Foxx and Joseph Gordon-Levitt, which was released on August 14, 2020, by Netflix. In 2021, she starred in Judas and the Black Messiah alongside Daniel Kaluuya, as Deborah Johnson, the partner of Fred Hampton and the expectant mother of Fred Hampton Jr.
Dominique Fishback is part of the project Transformers: Rise of the Beasts is scheduled to be released in the United States on June 9, 2023.