Anthony Ramos played Justin Laboy in Lin-Manuel Miranda’s short musical 21 Chump Street, a 14-minute, one-time performance on June 7, 2014, that was recorded for NPR’s This American Life. Ramos (left) performs with Hamilton castmates at the White House Hamilton opened off-Broadway in early 2015, with Ramos originating the dual roles of John Laurens and Alexander Hamilton’s eldest son Philip Hamilton. The musical moved to Broadway on July 13, 2015, in previews, and opened on August 6, 2015. Ramos left the production on November 20, 2016. In September 2016, it was announced that Ramos had been cast in director Spike Lee’s Netflix comedy-drama series She’s Gotta Have It, in the role of Mars Blackmon. Ramos played the role of Ramon in the 2018 remake of A Star Is Born, starring Lady Gaga and Bradley Cooper, and directed by Cooper.In 2018, Variety reported that Ramos had been cast as Usnavi de la Vega in the film adaptation of In the Heights.The movie was released in 2021 to significant acclaim, but failed at the box office.
In April 2021, Ramos was cast in the lead role in the next installment of the Transformers film franchise, Transformers: Rise of the Beasts. The film is currently scheduled to be released on June 9, 2023.